INSIGHT NICOTINE TULIP (10 TEST)

Cotinine is the first stage metabolite of nicotine, an alkaloid that produces stimulation of central nervous system (CNS).Nicotine is consumed either by smoking or chewing or snorting of tobacco. In addition to the tobacco, nicotine is also
available as nicotine gum, transdermal patches and nasal spray. In 24 hours urine, approximately 5% of a nicotine dose is
excreted as unchanged drug with 10% as cotinine and 35% as hydrocotinine. Elimination profile of cotinine is more stable
than unchanged nicotine. As a result, presence of cotinine in urine specimen is considered to be a good marker for
determination of nicotine use.