| HIV Acquired Immuno Deficiency Syndrome (AIDS) is caused by at least two retroviruses, the HIV-1 and the HIV-2, collectively referred to as HIV-1/2. Antibodies to HIV-1 envelope protein (gp120), transmembrane protein (gp 41) and HIV-2 transmembrane protein (gp36) are prevalent in sera of individuals with AIDS or AIDS related complex (ARC) or who are at high risk of contracting AIDS. Detection of these antibodies indicates exposure to the HIV-1/2 virus. HCV HCV is as single-stranded RNAvirus containing a linear genome with a length of about 9,600 nucleotides with positive polarity. It is now recognized that HCV infection is the major ethiological agent of post transfusion hepatitis type non-A, non-B, HCV infection frequently progresses to chronic liver disease. On the basis of phylogenetic analysis. HCV has been grouped into six major genotypes, each of which contains one or more subtypes. The distribution of HCV genotypes varies in different geographical areas. For the detection of HIV, synthetic peptides representing the highly immunodominant regions of HIV-1 &2 are coated on the ® membrane of COMBIQUIC . Combination of these peptides in a new generation assay format (advanced flow-through) affords specific and early detection of seroconversion following exposure to HIV. ® For the detection of HCV, COMBIQUIC employs recombinant protein derived from Core, NS3, NS4 and NS5 regions of the ® HCV genome. For its HCV- detection module, COMBIQUIC is a third generation assay the uses a cocktail of recombinant antigens derived from multiple HCV genotypes. |
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