Dengue virus (serotypes 1-4) belongs to the family of Flaviviridae, which is widely distributed in the epidemic and endemicareas throughout tropical and subtropical regions of the world. Dengue virus infection is considered significant in terms of morbidity, mortality and economic cost associated with it an estimated 100 million cases of dengue fever occurring throughout the world yearly. Dengue virus is transmitted in nature principally by the Aedes aegypti and Aedes albopictus mosquitoes. The mosquito vector is highly domesticated and an urban species. Dengue presents typically as a fever of sudden onset with headache, retro-orbital pain, pain in the back and limbs (break-bone fever), lymphadenopathy and maculopapular rash. Dengue virus infection is characterized by elevation in dengue virus specific NS 1 antigen level in patient’s blood stream from 1-6 days after onset of symptoms (Early phase). NS 1 is a new generation rapid Immunochromatographic test for first line detection of dengue virus infection in early stage |
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