Hepatitis E is caused by infection with the hepatitis E virus, a non-enveloped, single-stranded RNA virus. HEV is transmitted via the faecal-oral route. Hepatitis E is a waterborne disease, and contaminated water or food supplies have been implicated in major outbreaks. Hepatitis E virus causes acute sporadic and epidemic viral hepatitis. However, prolonged viraemia or faecal shedding are unusual and chronic infection does not occur. But, Hepatitis E is known to be fatal among pregnant women especially in the third semester. IgM antibodies to HEV are produced at an early stage of HEV infection and persist during the acute clinical illness. INSIGHT HEV-IgM, a rapid test for the detection of IgM antibodies to Hepatitis E virus in human serum or plasma enables diagnosis of the early and acute stage of infection |
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