INSIGHT RF TULIP (10 TEST)

Sometimes autoantibodies are produced by the human body against self antigens. The precise role that this aberrant immunity plays in the pathogenesis ofcerlain rheumatic diseases is unknown. However the presence ofthese autoantibodies serves as crediblemarkerofthe disease.In rheumatoid arthritis, diagnostically useful autoantibodies termed as”Rheumatoid factors”(RF) can be detected which are immunoglobulins of the class IgM, IgG, IgA and IgE. Practically, IgM class RF with specificity to human IgG (Fc) is the most useful prognostic marker of RA. The clinical significance of RF deteminations consists in differentiation beMeen rheumatoid arthritis, in which RF of modified IgM class have been demonstrated in the serum of approximately 80% of the cases examined and rheumatic fever, in which RF are almost always absent.INSIGHT-RFdetectsthepresence ofRheumatoidfactors in human serum, qualitatively, atconcentrationsas low as 10 IU/ml