Syphils is a sexually transmitted (venereal) disease caused by the spirochete Treponema pallidum, The disease can also be transmitted congenitally thereby attaining its importance in antenatal screening. After infection the host forms non-treponemal anti lipoidal antibodies (reagins) to the lipoidal material released from the damaged host cells as well as Treponema specific antibodies. Serological tests for non-treponemal antibodies such as VDRL, RPR, TRUST etc. are useful as screening tests. Tests for Treponema specific antibodies such as TPHA, FTA-ABS, rapid Treponema antibody tests are gaining importance as screening as well as confirmatory tests because they detect the presence of antibodies specific to Treponema pallidum. Syphicheck-WB is a modified TPHA, which qualitatively detects the presence of IgM and IgG class of Treponema specific antibodies during syphilis in whole blood, serum or plasma specimens within 15 minutes.
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